Cyclic AMP-induced chloride permeability in the apical membrane of necturus gallbladder epithelium

@article{Petersen1983CyclicAC,
  title={Cyclic AMP-induced chloride permeability in the apical membrane of necturus gallbladder epithelium},
  author={Kathryn Petersen and Luis Reuss},
  journal={The Journal of General Physiology},
  year={1983},
  volume={81},
  pages={705 - 729}
}
The effects of theophylline, 8-Br-cAMP, and cAMP on necturus gallbladder epithelium were investigated using microelectrode techniques. Each of these substances depolarized the cell membranes by approximately 15 mV and decreased the apparent ratio of apical to basolateral membrane resistances to a value not significantly different from zero. Examination of the ionic selectivity of the apical membrane by ion substitutions in the mucosal bathing medium revealed a large increase in Cl permeability… CONTINUE READING

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