Cyclic AMP-independent involvement of Rap1/B-Raf in the angiotensin II AT2 receptor signaling pathway in NG108-15 cells.

@article{Gendron2003CyclicAI,
  title={Cyclic AMP-independent involvement of Rap1/B-Raf in the angiotensin II AT2 receptor signaling pathway in NG108-15 cells.},
  author={Louis Gendron and Jean-François Oligny and Marcel Daniel Payet and Nicole Gallo-Payet},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 6},
  pages={3606-14}
}
The angiotensin II (Ang II) type 2 (AT(2)) receptor is an atypical seven-transmembrane domain receptor. Controversy surrounding this receptor concerns both the nature of the second messengers produced as well as its associated signaling mechanisms. Using the neuronal cell line NG108-15, we have reported previously that activation of the AT(2) receptor induced morphological differentiation in a p21(ras)-independent, but p42/p44(mapk)-dependent mechanism. The activation of p42/p44(mapk) was… CONTINUE READING
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