Cyclic AMP-dependent protein kinase opens chloride channels in normal but not cystic fibrosis airway epithelium

Abstract

Chloride (Cl–) secretion by the airway epithelium regulates, in part, the quantity and composition of the respiratory tract fluid, thereby facilitating mucociliary clearance. The rate of Cl– secretion is controlled by apical membrane Cl– channels1. Apical Cl– channels are opened and Cl– secretion is stimulated by a variety of hormones and neurotransmitters… (More)
DOI: 10.1038/331358a0

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