Cyclic AMP as a mitogenic signal for cultured rat Schwann cells

@article{Raff1978CyclicAA,
  title={Cyclic AMP as a mitogenic signal for cultured rat Schwann cells},
  author={Martin C. Raff and ANN HORNBY-SMITH and Jeremy P. Brockes},
  journal={Nature},
  year={1978},
  volume={273},
  pages={672-673}
}
THE possible role of intracellular cyclic AMP in the control of cell division is the subject of much controversial literature (reviewed in refs 1, 2). In most such studies fibroblastic cell lines have been used, and various manipulations which raise intracellular concentration of cyclic AMP have been reported to inhibit cell proliferation1. Here we show that highly purified Schwann cells in dissociated cell cultures of newborn rat nerve, which divide infrequently in 10% serum, are stimulated to… CONTINUE READING

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