Cyclic AMP and c-myc gene expression in PY815 mouse mastocytoma cells.

@article{Gros1985CyclicAA,
  title={Cyclic AMP and c-myc gene expression in PY815 mouse mastocytoma cells.},
  author={J E Le Gros and R de Feyter and Ray K. Ralph},
  journal={FEBS letters},
  year={1985},
  volume={186 1},
  pages={13-6}
}
The possibility was examined that inhibition of growth of PY815 mouse mastocytoma cells by N6,O2'-dibutyryladenosine 3',5'-cyclic monophosphate (DB cyclic AMP) results from inhibition of c-myc gene expression. Temporary increases in c-myc RNA which occurred soon after DB cyclic AMP treatment and upon removal of the drug were not consistent with direct inhibition of c-myc gene expression by DB cyclic AMP. The increases in c-myc RNA coincided with the passage through, or accumulation of cells in… CONTINUE READING