Cyclic AMP accumulation in rat soleus muscle: stimulation by beta2- but not beta3-adrenoceptors.

@article{Roberts1998CyclicAA,
  title={Cyclic AMP accumulation in rat soleus muscle: stimulation by beta2- but not beta3-adrenoceptors.},
  author={Stewart J Roberts and Roger J Summers},
  journal={European journal of pharmacology},
  year={1998},
  volume={348 1},
  pages={53-60}
}
The beta-adrenoceptor subtypes involved in cyclic AMP accumulation in rat soleus muscle were studied using beta1- beta2- and beta3-adrenoceptor agonists and antagonists. Responses to (-)-isoprenaline were antagonised by (-)-propranolol (p KB = 8.32 at 0.1 microM) and by erythro-DL-1(7-methylindian-4-yloxy)-3-isopropylaminobuta n-2-ol (+/-)-ICI 118551) (pKB = 9.38 at 10 nM and 9.65 at 100 nM) but not by 2-hydroxy-5(2-((2-hydroxy-3-(4-((1-methyl-4-trifluoromethyl)1H-imidazole -2-yl)-phenoxy… CONTINUE READING

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