Cyclic AMP-Responsive Element-Binding Protein (CREB) is Critical in Autoimmunity by Promoting Th17 but Inhibiting Treg Cell Differentiation

@inproceedings{Wang2017CyclicAE,
  title={Cyclic AMP-Responsive Element-Binding Protein (CREB) is Critical in Autoimmunity by Promoting Th17 but Inhibiting Treg Cell Differentiation},
  author={XiaoHu Wang and Lu wen Ni and Dehui Chang and Huiping Lu and Yu Jiang and Byung-Seok Kim and Aibo Wang and Xindong Liu and Bo Zhong and Xuexian O. Yang and Chen Dong},
  booktitle={EBioMedicine},
  year={2017}
}
The molecular mechanisms that govern differential T cell development into pro-inflammatory Th17 vs. regulatory T (Treg) cells remain unclear. Here, we show that selective deletion of CREB in T cells or Th17 cells impaired Th17 cell differentiation in vitro and in vivo, and led to resistance to autoimmune diseases. Mechanistically, CREB, activated by CD3-PKC-ϴ signaling, plays a key role in regulating Th17 cell differentiation, at least in part through directly binding to the Il17-Il17f gene… CONTINUE READING
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