Cyclic AMP Mimics the Anti-ageing Effects of Calorie Restriction by Up-Regulating Sirtuin

@inproceedings{Wang2015CyclicAM,
  title={Cyclic AMP Mimics the Anti-ageing Effects of Calorie Restriction by Up-Regulating Sirtuin},
  author={Zhuoran Wang and Lu Zhang and Yaru Liang and Chi Zhang and Zhiyu Xu and Lang Zhang and Ryosuke Fuji and Wei Jun Mu and Liyuan Li and Junjun Jiang and Yong Ju and Zhao Wang},
  booktitle={Scientific reports},
  year={2015}
}
Cyclic adenosine monophosphate (cAMP) plays an important role in many biological processes as a second messenger, and cAMP treatment has been reported to extend the lifespan of wild-type Drosophila melanogaster. Our study showed that exogenous cAMP improved ageing-related phenotypes by increasing the protein level of Sirtuins, which prevented metabolic disorders to mimic the effect of calorie restriction. Experiments in vitro showed that cAMP directly bound to SIRT1 and SIRT3 and consequently… CONTINUE READING
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