Cyclic ADP-ribose is a second messenger in the lipopolysaccharide-stimulated activation of murine N9 microglial cell line.

@article{Franco2006CyclicAI,
  title={Cyclic ADP-ribose is a second messenger in the lipopolysaccharide-stimulated activation of murine N9 microglial cell line.},
  author={Luisa Franco and Nicoletta Bodrato and Iliana Moreschi and Cesare Usai and Santina Bruzzone and Sonia Scarf {\`i} and Elena Zocchi and Antonio De Flora},
  journal={Journal of neurochemistry},
  year={2006},
  volume={99 1},
  pages={165-76}
}
Lipopolysaccharide, the main component of the cell wall of Gram-negative bacteria, is known to activate microglial cells following its interaction with the CD14/Toll-like receptor complex (TLR-4). The activation pathway triggered by lipopolysaccharide in microglia involves enhanced basal levels of intracellular calcium ([Ca2+]i) and terminates with increased generation of cytokines/chemokines and nitric oxide. Here we demonstrate that in lipopolysaccharide-stimulated murine N9 microglial cells… CONTINUE READING
11 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 11 extracted citations

Similar Papers

Loading similar papers…