Cyclic ADP-ribose in insulin secretion from pancreatic beta cells.

  title={Cyclic ADP-ribose in insulin secretion from pancreatic beta cells.},
  author={Shin Takasawa and Koji Nata and Hideto Yonekura and Hiroshi Okamoto},
  volume={259 5093},
Inositol 1,4,5-trisphosphate (IP3) is thought to be a second messenger for intracellular calcium mobilization. However, in a cell-free system of islet microsomes, cyclic adenosine diphosphate-ribose (cADP-ribose), a nicotinamide adenine dinucleotide (NAD+) metabolite, but not IP3, induced calcium release. In digitonin-permeabilized islets, cADP-ribose and calcium, but not IP3, induced insulin secretion. Islet microsomes released calcium when combined with the extract from intact islets that had… CONTINUE READING


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