Cycles of chromosome instability are associated with a fragile site and are increased by defects in DNA replication and checkpoint controls in yeast.

@article{Admire2006CyclesOC,
  title={Cycles of chromosome instability are associated with a fragile site and are increased by defects in DNA replication and checkpoint controls in yeast.},
  author={Anthony A Admire and Lisa Shanks and Nicole M Danzl and Mei Wang and Ulli Weier and William jun. Folsom Stevens and Elizabeth Kathrina Hunt and Ted A. Weinert},
  journal={Genes & development},
  year={2006},
  volume={20 2},
  pages={
          159-73
        }
}
We report here that a normal budding yeast chromosome (ChrVII) can undergo remarkable cycles of chromosome instability. The events associated with cycles of instability caused a distinctive "sectoring" of colonies on selective agar plates. We found that instability initiated at any of several sites on ChrVII, and was sharply increased by the disruption of DNA replication or by defects in checkpoint controls. We studied in detail the cycles of instability associated with one particular… CONTINUE READING

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