Cycle arrest and aneuploidy induced by zidovudine in murine embryonic stem cells.

@article{Campos2012CycleAA,
  title={Cycle arrest and aneuploidy induced by zidovudine in murine embryonic stem cells.},
  author={Priscila Britto Campos and Rafaela Costa Sartore and Bia L. Ramalho and Elaine S. Costa and Stevens K. Rehen},
  journal={Mutagenesis},
  year={2012},
  volume={27 4},
  pages={431-6}
}
Zidovudine (3'-azido-3'-deoxythymidine; AZT) is a nucleoside analogue widely used for the treatment of acquired immune deficiency syndrome (AIDS). Medical guidelines recommend the use of AZT by pregnant women in order to reduce risk of HIV vertical transmission. Although it is efficacious, little is known about the side effects of AZT on embryonic development. In this sense, we used murine embryonic stem (mES) cells as a model to investigate the consequences of AZT exposure for embryogenesis… CONTINUE READING
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