Cyclazocine: comparison to hydromorphone and interaction with cocaine.

  title={Cyclazocine: comparison to hydromorphone and interaction with cocaine.},
  author={Kenzie L Preston and Annie Umbricht and J. R. Schroeder and Mary E. Abreu and David H. Epstein and Wallace B. Pickworth},
  journal={Behavioural pharmacology},
  volume={15 2},
Kappa-opioid agonists produce neurobiological and behavioral effects opposite to those of cocaine and may be useful for the treatment of cocaine dependence. To evaluate the kappa- and mu-agonist effects of cyclazocine and to test whether cyclazocine pretreatment would attenuate the effects of cocaine, healthy, male and female, experienced opiate and cocaine users (n = 13) were enrolled in a two-phase study. In Phase 1, placebo, cyclazocine (0.2, 0.4 and 0.8 mg) and the mu-agonist hydromorphone… CONTINUE READING