Cycad neurotoxins, consumption of flying foxes, and ALS-PDC disease in Guam.

@article{Cox2002CycadNC,
  title={Cycad neurotoxins, consumption of flying foxes, and ALS-PDC disease in Guam.},
  author={Paul Alan Cox and Oliver W. Sacks},
  journal={Neurology},
  year={2002},
  volume={58 6},
  pages={
          956-9
        }
}
The Chamorro people of Guam have been afflicted with a complex of neurodegenerative diseases (now known as ALS-PDC) with similarities to ALS, AD, and PD at a far higher rate than other populations throughout the world. Chamorro consumption of flying foxes may have generated sufficiently high cumulative doses of plant neurotoxins to result in ALS-PDC neuropathologies, since the flying foxes forage on neurotoxic cycad seeds. 

Citations

Publications citing this paper.
SHOWING 1-10 OF 131 CITATIONS, ESTIMATED 56% COVERAGE

Neurodegenerative Diseases

VIEW 10 EXCERPTS
CITES RESULTS & BACKGROUND
HIGHLY INFLUENCED

Contributions of isolated Pacific populations to understanding neurodegenerative diseases.

VIEW 7 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Potential for dietary exposure to &bgr;‐N‐methylamino‐L‐alanine and microcystin from a freshwater system

VIEW 6 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Spinal cord: motor neuron diseases.

VIEW 16 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Animal models of BMAA neurotoxicity: a critical review.

VIEW 9 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2002
2019

CITATION STATISTICS

  • 8 Highly Influenced Citations

  • Averaged 10 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 38 REFERENCES

Pesticide bioaccumulation in cattle

  • C Cullen-Murray, DW Connel
  • Ecotoxicol Environ Saf
  • 1994

Food plants and economic importance of flying foxes on Pacific Islands

  • GJ Wiles, MS Fujita
  • Biological Report
  • 1992

History of fruit bat use , research , and protection in the Northern Mariana Islands

  • TO Lemke
  • Biological Report
  • 1992

Local policies and protection by the government of Guam

  • R Lujan
  • Biological Report
  • 1992

Recent trends in the fruit bat trade on Guam

  • GJ Wiles
  • logical Report
  • 1992