Cybernetic model predictive control of a continuous bioreactor with cell recycle.

  title={Cybernetic model predictive control of a continuous bioreactor with cell recycle.},
  author={Kapil G. Gadkar and Francis J. Doyle and Timothy J. Crowley and Jeffrey D. Varner},
  journal={Biotechnology progress},
  volume={19 5},
The control of poly-beta-hydroxybutyrate (PHB) productivity in a continuous bioreactor with cell recycle is studied by simulation. A cybernetic model of PHB synthesis in Alcaligenes eutrophus is developed. Model parameters are identified using experimental data, and simulation results are presented. The model is interfaced to a multirate model predictive control (MPC) algorithm. PHB productivity and concentration are controlled by manipulating dilution rate and recycle ratio. Unmeasured time… CONTINUE READING
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