Cyanosilylation at pregnane side-chains. Selective synthesis and crystal structure of 20(R)-silylated cyanohydrins.

Abstract

Trimethylsilylcyanide addition to different carbonyl moieties, i.e. saturated ketones, an enone and an aldehyde, at the steroid side-chain, was studied in the presence of a convenient catalyst. Depending on the nature of the carbonyl group, different outcomes were noticed. Saturated 20-keto pregnanes yielded epimerically pure silylated cyanohydrins, being… (More)

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@article{Silva2005CyanosilylationAP, title={Cyanosilylation at pregnane side-chains. Selective synthesis and crystal structure of 20(R)-silylated cyanohydrins.}, author={Maria Manuel Cruz Silva and Lourdes C R Andrade and Jos{\'e} Ant{\'o}nio Paix{\~a}o and Maria Jos{\'e} Pinheiro Minora de Almeida and M Luisa S{\'a} e Melo}, journal={Steroids}, year={2005}, volume={70 3}, pages={145-51} }