Cyanogen as a selective probe for carbonic anhydrase hydrolase activity.

Abstract

The salt bridge probe cyanogen (ethanedinitrile, C2N2; N identical to C-C identical to N) inhibits the bovine carbonic anhydrase (EC 4.2.1.1.) hydrolase activity toward various types of esters without significant effect on its hydrolyase activity. Two sets of pyridine derivatives that were isosteric substrates for the two activities were differentially… (More)

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