Cyanobacteria, neurotoxins and water resources: Are there implications for human neurodegenerative disease?

@article{Metcalf2009CyanobacteriaNA,
  title={Cyanobacteria, neurotoxins and water resources: Are there implications for human neurodegenerative disease?},
  author={James S Metcalf and Geoffrey A. Codd},
  journal={Amyotrophic Lateral Sclerosis},
  year={2009},
  volume={10},
  pages={74 - 78}
}
  • J. MetcalfG. Codd
  • Published 1 January 2009
  • Environmental Science
  • Amyotrophic Lateral Sclerosis
Abstract Cyanobacteria are cosmopolitan microbes that inhabit marine, freshwater and terrestrial environments. Under favourable conditions in waterbodies, they can form massive populations (blooms and scums), which present hazards to human and animal health. Such cyanobacteria often contain a variety of toxic substances (cyanotoxins) that can exist as both cell-associated and free forms in the surrounding water. Some cyanotoxins are highly neurotoxic and act through a variety of mechanisms… 

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References

SHOWING 1-10 OF 40 REFERENCES

Cyanobacterial toxins: risk management for health protection.

Production of the Neurotoxin BMAA by a Marine Cyanobacterium

Diverse species of cyanobacteria have recently been discovered to produce the neurotoxic non-protein amino acid β-methylamino-L-alanine (BMAA). In Guam, BMAA has been studied as a possible

A mechanism for slow release of biomagnified cyanobacterial neurotoxins and neurodegenerative disease in Guam.

  • S. MurchP. CoxS. Banack
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2004
It is reported that BMAA occurs not only as a free amino acid in the Guam ecosystem but also can be released from a bound form by acid hydrolysis, which may explain the observed long latency period for neurological disease onset among the Chamorro people.

Cyanobacterial toxins, exposure routes and human health

Advances in the recognition of cyanobacterial toxins and their toxicity, and of the exposure routes with reference to human health, namely via skin contact, inhalation, haemodialysis and ...

Biomagnification of cyanobacterial neurotoxins and neurodegenerative disease among the Chamorro people of Guam

  • P. CoxS. BanackS. Murch
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2003
The biomagnification of BMAA through the Guam ecosystem fits a classic triangle of increasing concentrations of toxic compounds up the food chain, which may explain why the incidence of ALS-PDC among the Chamorro was 50-100 times the occurrence of amyotrophic lateral sclerosis elsewhere.

Analysis of cyanobacterial toxins by physicochemical and biochemical methods.

A review is presented of developments in the detection and analysis of cyanobacterial toxins, other than bioassays, including application of physicochemical, immunoassay, and enzyme-based methods.

Cyanobacterial neurotoxin BMAA in ALS and Alzheimer’s disease

Objective –  The aim of this study was to screen for and quantify the neurotoxic amino acid β‐N‐methylamino‐l‐alanine (BMAA) in a cohort of autopsy specimens taken from Alzheimer’s disease (AD),

Diverse taxa of cyanobacteria produce beta-N-methylamino-L-alanine, a neurotoxic amino acid.

  • P. CoxS. Banack B. Bergman
  • Biology, Environmental Science
    Proceedings of the National Academy of Sciences of the United States of America
  • 2005
It is reported here that a single neurotoxin, beta-N-methylamino-L-alanine, may be produced by all known groups of cyanobacteria, including cyanobacterial symbionts and free-living cyanob bacteria.

Human fatalities from cyanobacteria: chemical and biological evidence for cyanotoxins.

It is concluded that the major contributing factor to death of the dialyses patients was intravenous exposure to microcystins, specificallymicrocystin-YR, -LR, and -AR.