Cyanoacetylation of 5-Aminopyrazole : Synthesis of 2-( 1-Aryl-4-substituted pyrazolo [ 3 , 4-d ] pyrimidin-6-yl ) acetonitrile Derivatives

@inproceedings{Salaheldin2009CyanoacetylationO5,
  title={Cyanoacetylation of 5-Aminopyrazole : Synthesis of 2-( 1-Aryl-4-substituted pyrazolo [ 3 , 4-d ] pyrimidin-6-yl ) acetonitrile Derivatives},
  author={Abdellatif Mohamed Salaheldin},
  year={2009}
}
N1-Substituted-5-amino-4-cyanopyrazoles were cyanoacetylated with a mixture of cyanoacetic acid and acetic anhydride. Cyclization with POCl3 gave 4-chloro-pyrazolo[3,4-d]pyrimidine derivatives. From the reaction with hydrazine and arylhydrazines, the hydrazinyls and their oxidized forms, the azo products, were obtained. The structure of the compounds… CONTINUE READING