Cyanide induces protein kinase C translocation: blockade by NMDA antagonists.

@article{Rathinavelu1994CyanideIP,
  title={Cyanide induces protein kinase C translocation: blockade by NMDA antagonists.},
  author={Appu Rathinavelu and Peng Sun and Goran Pavlakovi{\'c} and Joseph L. Borowitz and Gary E. Isom},
  journal={Journal of biochemical toxicology},
  year={1994},
  volume={9 5},
  pages={235-40}
}
Activation and translocation of protein kinase C (PKC) during KCN-induced histotoxic hypoxia was studied in rat brain slices prepared from cerebellum, hippocampus, and cortex. Treatment with 1-10 mM KCN produced a significant increase in PKC translocation and enzyme activity in the particulate fraction of cerebellar and hippocampal slices. In cortical slices, PKC activity was not affected by cyanide treatment. The membrane-associated PKC activity reached a maximum 30 minutes after incubation… CONTINUE READING