Cyanide adducts with human plasma proteins: albumin as a potential exposure surrogate.

@article{Fasco2007CyanideAW,
  title={Cyanide adducts with human plasma proteins: albumin as a potential exposure surrogate.},
  author={Michael J Fasco and Charles R. Hauer and Robert F Stack and Colleen O'hehir and John R. Barr and George Eadon},
  journal={Chemical research in toxicology},
  year={2007},
  volume={20 4},
  pages={677-84}
}
Cyanide (CN) is a ubiquitous environmental toxicant. The measurement of CN in whole blood is a common exposure assay, but values are error prone because of CN's rapid metabolism and clearance (t1/2 < 1 h) from this compartment. This study was undertaken to determine whether CN forms covalent adduct(s) with plasma proteins that could serve as stable biomarker(s) and potential surrogate(s) of exposure. When added to human blood, plasma, or serum, CN formed covalent adducts with immunoglobulin G… CONTINUE READING