CyLoP-1: Membrane-active peptide with cell-penetrating and antimicrobial properties.

@article{Ponnappan2017CyLoP1MP,
  title={CyLoP-1: Membrane-active peptide with cell-penetrating and antimicrobial properties.},
  author={Nisha Ponnappan and Deepthi Poornima Budagavi and Archana Chugh},
  journal={Biochimica et biophysica acta. Biomembranes},
  year={2017},
  volume={1859 2},
  pages={
          167-176
        }
}
CyLoP-1 is a cysteine-rich cell-penetrating peptide derived from nuclear localization sequence of snake toxin, crotamine. The peptide has shown cytoplasmic uptake in mammalian cells at lower concentrations. In the present study, the cell-penetrating and antimicrobial activity of the peptide has been studied by employing mammalian cells, plant cells as well as bacterial and fungal pathogens. The study shows that the peptide acts as an effective CPP and a cargo-delivery vector for not only… CONTINUE READING
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