Cxcl12 evolution--subfunctionalization of a ligand through altered interaction with the chemokine receptor.

@article{Boldajipour2011Cxcl12EO,
  title={Cxcl12 evolution--subfunctionalization of a ligand through altered interaction with the chemokine receptor.},
  author={Bijan Boldajipour and Maria Doitsidou and Katsiaryna Tarbashevich and Cedric Laguri and Shuizi Rachel Yu and Jonas Ries and Karin Dumstrei and S. Thelen and Julia D{\"o}rries and Eric Messerschmidt and Marcus Thelen and Petra Schwille and Michael P. Brand and Hugues Lortat-Jacob and Erez Raz},
  journal={Development},
  year={2011},
  volume={138 14},
  pages={
          2909-14
        }
}
The active migration of primordial germ cells (PGCs) from their site of specification towards their target is a valuable model for investigating directed cell migration within the complex environment of the developing embryo. In several vertebrates, PGC migration is guided by Cxcl12, a member of the chemokine superfamily. Interestingly, two distinct Cxcl12 paralogs are expressed in zebrafish embryos and contribute to the chemotattractive landscape. Although this offers versatility in the use of… CONTINUE READING

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