Cx43 reverses the resistance of A549 lung adenocarcinoma cells to cisplatin by inhibiting EMT.

@article{Yu2014Cx43RT,
  title={Cx43 reverses the resistance of A549 lung adenocarcinoma cells to cisplatin by inhibiting EMT.},
  author={Meiling Yu and Cuiling Zhang and Li Li and Shuying Dong and Naiju Zhang and Xu-hui Tong},
  journal={Oncology reports},
  year={2014},
  volume={31 6},
  pages={2751-8}
}
Cisplatin (CDDP) is one of the standard first-line chemotherapeutic agents for advanced non-small cell lung cancer (NSCLC). Unfortunately, prolonged exposure to CDDP results in acquired resistance which prevents the successful treatment of lung cancer patients. Thus, it is necessary to explore the mechanism underlying the resistance of NSCLC to CDDP. In the present study, a CDDP-resistant human lung cancer cell line A549/CDDP was established from the parental cell line A549. The results… CONTINUE READING