Cux1 and Cux2 Regulate Dendritic Branching, Spine Morphology, and Synapses of the Upper Layer Neurons of the Cortex

@article{Cubelos2010Cux1AC,
  title={Cux1 and Cux2 Regulate Dendritic Branching, Spine Morphology, and Synapses of the Upper Layer Neurons of the Cortex},
  author={Beatriz Cubelos and Alvaro Sebasti{\'a}n-Serrano and Leonardo Beccari and Maria Elisa Calcagnotto and Elsa Cisneros and Seonhee Kim and Ana Dopazo and Manuel {\'A}lvarez-Dolado and Juan Miguel Redondo and Paola Bovolenta and Christopher A. Walsh and Marta Ramos M. Nieto},
  journal={Neuron},
  year={2010},
  volume={66},
  pages={523-535}
}
Dendrite branching and spine formation determines the function of morphologically distinct and specialized neuronal subclasses. However, little is known about the programs instructing specific branching patterns in vertebrate neurons and whether such programs influence dendritic spines and synapses. Using knockout and knockdown studies combined with morphological, molecular, and electrophysiological analysis, we show that the homeobox Cux1 and Cux2 are intrinsic and complementary regulators of… CONTINUE READING
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