Cutting proteins within lipid bilayers: rhomboid structure and mechanism.

  title={Cutting proteins within lipid bilayers: rhomboid structure and mechanism.},
  author={Marius K Lemberg and Matthew Freeman},
  journal={Molecular cell},
  volume={28 6},
Rhomboids were only discovered to be novel proteases in 2001, but progress on understanding this newest family of intramembrane proteases has been rapid. They are now the best characterized of these rather mysterious enzymes that cleave transmembrane domains within the lipid bilayer. In particular, the biochemical analysis of solubilized rhomboids and, most recently, a flurry of high-resolution crystal structures, have led to real insight into their enzymology. Long-standing questions about how… CONTINUE READING

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