Cutting edge: the natural ligand for glucocorticoid-induced TNF receptor-related protein abrogates regulatory T cell suppression.

Abstract

CD4(+)25(+) regulatory T (Treg) cells maintain immunological self-tolerance through mechanisms that are only in part understood. Previous studies suggest that the glucocorticoid-induced TNFR-related protein (GITR), which is preferentially expressed on the surface of Treg cells, potentially provides a signal that abrogates Treg suppression. In this study, we… (More)

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@article{Ji2004CuttingET, title={Cutting edge: the natural ligand for glucocorticoid-induced TNF receptor-related protein abrogates regulatory T cell suppression.}, author={Hong-bin Ji and Gongxian Liao and William A. Faubion and Ana Clara Abad{\'i}a-Molina and Cristina Cozzo and F. Stephen Laroux and A. T. Caton and Cox Terhorst}, journal={Journal of immunology}, year={2004}, volume={172 10}, pages={5823-7} }