Cutting edge: inhibitory effects of CD4 and CD8 on T cell activation induced by high-affinity noncognate ligands.

Abstract

It has been proposed that MHC restriction during thymocyte selection is controlled by coreceptor (CD4 or CD8) sequestration of the signaling molecule Lck. We explored this model as a mechanism for preventing peripheral T cell activation due to non-MHC ligand cross-reactivities of TCRs. TCRs that have a range of affinities for a class I MHC ligand were… (More)
DOI: 10.4049/jimmunol.0901664

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@article{Chervin2009CuttingEI, title={Cutting edge: inhibitory effects of CD4 and CD8 on T cell activation induced by high-affinity noncognate ligands.}, author={Adam S. Chervin and Jennifer D. Stone and Natalie A. Bowerman and David M. Kranz}, journal={Journal of immunology}, year={2009}, volume={183 12}, pages={7639-43} }