Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex.

Abstract

Human heat shock protein 60 (hsp60) elicits a potent proinflammatory response in cells of the innate immune system and therefore has been proposed as a danger signal of stressed or damaged cells. We report here that macrophages of C3H/HeJ mice, carrying a mutant Toll-like-receptor (Tlr) 4 are nonresponsive to hsp60. Both the induction of TNF-alpha and NO… (More)

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@article{Ohashi2000CuttingEH, title={Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex.}, author={Kimiko Ohashi and Volker Burkart and Stefanie B. Floh{\'e} and H-A. Kolb}, journal={Journal of immunology}, year={2000}, volume={164 2}, pages={558-61} }