Cutting edge: CD83 regulates the development of cellular immunity.

Abstract

We recently found that human CD83, a marker of mature dendritic cells, is an adhesion receptor that binds to resting monocytes and a subset of activated CD8(+) T cells. We injected CD83-Ig into mice transplanted with the immunogenic P815 mastocytoma and showed that it significantly enhanced the rate of tumor growth and inhibited the development of cytotoxic T cells. In contrast, mice immunized with CD83-transfected K1735 cells, a poorly immunogenic melanoma, could prevent the outgrowth of wild-type K1735 cells. Studies performed in vitro with human PBL showed that coimmobilized CD83-Ig and anti-CD3 enhanced T cell proliferation and increased the proportion of CD8(+) T cells. CD83-transfected B-lymphoblastoid T51 cells stimulated T cell proliferation more effectively than untransfected T51 cells in MLR cultures and increased the generation of cytolytic T cells. We conclude that CD83 is a functionally important receptor that can regulate the development of cellular immunity by interacting with its ligand(s).

Extracted Key Phrases

6 Figures and Tables

Statistics

0100200300'03'05'07'09'11'13'15'17
Citations per Year

891 Citations

Semantic Scholar estimates that this publication has 891 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Scholler2002CuttingEC, title={Cutting edge: CD83 regulates the development of cellular immunity.}, author={Nathalie Scholler and Martha S Hayden-Ledbetter and Amber Dahlin and Ingegerd Hellstr{\"{o}m and Karl Erik Hellstr{\"{o}m and Jeffrey A . Ledbetter}, journal={Journal of immunology}, year={2002}, volume={168 6}, pages={2599-602} }