Cutting edge: the dependence of plasma cells and independence of memory B cells on BAFF and APRIL.

@article{Benson2008CuttingET,
  title={Cutting edge: the dependence of plasma cells and independence of memory B cells on BAFF and APRIL.},
  author={M Jedorah Benson and Stacey R. Dillon and Emanuela Castigli and Raif S Geha and Shengli Xu and Kong-Peng Lam and Randolph J. Noelle},
  journal={Journal of immunology},
  year={2008},
  volume={180 6},
  pages={3655-9}
}
Memory B (B(MEM)) cells and long-lived bone marrow plasma cells (BM-PCs) persist within local environmental survival niches that afford cellular longevity. However, the factors supporting B(MEM) cell survival within the secondary lymphoid organs and allowing BM-PC persistence in the bone marrow remain poorly characterized. We report herein that long-lived B(MEM) cell survival and function are completely independent of BAFF (B cell-activating factor of the TNF family) or APRIL (a proliferation… CONTINUE READING
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