Cutting edge: the Ets1 transcription factor is required for the development of NK T cells in mice.

@article{Walunas2000CuttingET,
  title={Cutting edge: the Ets1 transcription factor is required for the development of NK T cells in mice.},
  author={Theresa L. Walunas and Bo Wang and C. R. Wang and Jeffrey M. Leiden},
  journal={Journal of immunology},
  year={2000},
  volume={164 6},
  pages={2857-60}
}
Ets1-deficient mice develop B and T cells but display a severe defect in the development of the NK cell lineage. In this report, we demonstrate that Ets1 is also required for the development of NK1.1+ T (NK T) cells. We observed significantly decreased numbers of NK T cells in the thymus, spleen, and liver of Ets1-deficient mice. These organs also contained markedly decreased levels of the canonical Valpha14-Jalpha281 TCRalpha transcript seen in NK T cells. Unlike wild-type NK T cells, Ets1… CONTINUE READING

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