Cutting edge: species-specific TLR9-mediated recognition of CpG and non-CpG phosphorothioate-modified oligonucleotides.

@article{Roberts2005CuttingES,
  title={Cutting edge: species-specific TLR9-mediated recognition of CpG and non-CpG phosphorothioate-modified oligonucleotides.},
  author={Tara Laurine Roberts and Matthew J Sweet and David A Hume and Katryn J. Stacey},
  journal={Journal of immunology},
  year={2005},
  volume={174 2},
  pages={605-8}
}
Different DNA motifs are required for optimal stimulation of mouse and human immune cells by CpG oligodeoxynucleotides (ODN). These species differences presumably reflect sequence differences in TLR9, the CpG DNA receptor. In this study, we show that this sequence specificity is restricted to phosphorothioate (PS)-modified ODN and is not observed when a natural phosphodiester backbone is used. Thus, human and mouse cells have not evolved to recognize different CpG motifs in natural DNA… CONTINUE READING

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