Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins.

@article{Takeuchi2002CuttingER,
  title={Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins.},
  author={Osamu Takeuchi and Shintaro Sato and Takao Horiuchi and Katsuaki Hoshino and Kiyoshi Takeda and Zhongyun Dong and Robert L Modlin and Shizuo Akira},
  journal={Journal of immunology},
  year={2002},
  volume={169 1},
  pages={10-4}
}
The Toll-like receptor (TLR) family acts as pattern recognition receptors for pathogen-specific molecular patterns (PAMPs). TLR2 is essential for the signaling of a variety of PAMPs, including bacterial lipoprotein/lipopeptides, peptidoglycan, and GPI anchors. TLR6 associates with TLR2 and recognizes diacylated mycoplasmal lipopeptide along with TLR2. We report here that TLR1 associates with TLR2 and recognizes the native mycobacterial 19-kDa lipoprotein along with TLR2. Macrophages from TLR1… CONTINUE READING
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