Cutting edge: role of STAT1, STAT3, and STAT5 in IFN-alpha beta responses in T lymphocytes.

@article{Tanabe2005CuttingER,
  title={Cutting edge: role of STAT1, STAT3, and STAT5 in IFN-alpha beta responses in T lymphocytes.},
  author={Yoshinari Tanabe and Takeaki Nishibori and Leon L Su and Robert M. Arduini and D. P. 7326 Baker and Michael W. David},
  journal={Journal of immunology},
  year={2005},
  volume={174 2},
  pages={609-13}
}
Engagement of the IFN-alphabeta receptor initiates multiple signaling cascades, including activation of the STAT. In this study, we demonstrate that IFN-alphabeta, although antiproliferative in wild-type CD4(+) or CD8(+) T cells, act as strong mitogens on their STAT1(-/-) counterparts. Furthermore, IFN-alphabeta exert little effect on apoptosis in wild-type cells, but are potent survival factors in the absence of STAT1. The antiapoptotic response in the absence of STAT1 is predominantly… CONTINUE READING

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