Cutting edge: prostaglandin D2 enhances leukotriene C4 synthesis by eosinophils during allergic inflammation: synergistic in vivo role of endogenous eotaxin.

@article{MesquitaSantos2006CuttingEP,
  title={Cutting edge: prostaglandin D2 enhances leukotriene C4 synthesis by eosinophils during allergic inflammation: synergistic in vivo role of endogenous eotaxin.},
  author={Fabio P. Mesquita-Santos and Adriana Vieira-de-Abreu and Andrea Surrage Calheiros and Isabela H. Figueiredo and Hugo Caire de Castro-Faria-Neto and Peter F. Weller and Patr{\'i}cia Torres Bozza and Bruno Lourenço Diaz and Christianne Bandeira-Melo},
  journal={Journal of immunology},
  year={2006},
  volume={176 3},
  pages={1326-30}
}
In addition to the well-recognized ability of prostaglandin D2 (PGD2) to regulate eosinophil trafficking, we asked whether PGD2 was also able to activate eosinophils and control their leukotriene C4 (LTC4)-synthesizing machinery. PGD2 administration to presensitized mice enhanced in vivo LTC4 production and formation of eosinophil lipid bodies-potential LTC4-synthesizing organelles. Immunolocalization of newly formed LTC4 demonstrated that eosinophil lipid bodies were the sites of LTC4… CONTINUE READING