Cutting edge: priming of CD8 T cell immunity to herpes simplex virus type 1 requires cognate TLR3 expression in vivo.

@article{Davey2010CuttingEP,
  title={Cutting edge: priming of CD8 T cell immunity to herpes simplex virus type 1 requires cognate TLR3 expression in vivo.},
  author={Gayle M Davey and Magdalena Wojtasiak and Anna I. Proietto and Francis Robert Carbone and William R Heath and Sammy Bedoui},
  journal={Journal of immunology},
  year={2010},
  volume={184 5},
  pages={2243-6}
}
Despite its potential for involvement in viral immunity, little evidence links TLR3 to adaptive antiviral responses. Here we show that TLR3 is required for the generation of CD8 T cell immunity to HSV-1. The magnitude of the gB-specific CD8 T cell response after flank infection by HSV-1 was significantly reduced in mice lacking TIR domain-containing adaptor-inducing IFN-beta or TLR3, but not MyD88. Impaired CTL induction was evident in chimeric mice lacking TLR3 in bone marrow (BM)-derived… CONTINUE READING
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