Cutting edge: precursor frequency affects the helper dependence of cytotoxic T cells.

@article{Mintern2002CuttingEP,
  title={Cutting edge: precursor frequency affects the helper dependence of cytotoxic T cells.},
  author={Justine D Mintern and Gayle M Davey and Gabrielle T. Belz and Francis Robert Carbone and William R Heath},
  journal={Journal of immunology},
  year={2002},
  volume={168 3},
  pages={
          977-80
        }
}
Generation of CTL immunity often depends on the availability of CD4 T cell help. In this report, we show that CTL responses induced by cross-priming can be converted from CD4-dependent to CD4-independent by increasing the frequency of CTL precursors. In the absence of CD4 T cells, high numbers of CTL precursors were able to expand in number and become effector CTL. The ability of high frequencies of CD8 T cells to override help was not due to their ability to signal CD40 via expression of CD154… CONTINUE READING
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