Cutting edge: negative regulation of immune synapse formation by anchoring lipid raft to cytoskeleton through Cbp-EBP50-ERM assembly.

@article{Itoh2002CuttingEN,
  title={Cutting edge: negative regulation of immune synapse formation by anchoring lipid raft to cytoskeleton through Cbp-EBP50-ERM assembly.},
  author={Katsuhiko Itoh and Masahiro Sakakibara and Sho Yamasaki and Arata Takeuchi and Hisashi Arase and Masaru Miyazaki and Nobuyuki Nakajima and Masato Okada and Takashi K. Saito},
  journal={Journal of immunology},
  year={2002},
  volume={168 2},
  pages={541-4}
}
Ag recognition by T lymphocytes induces immune synapse formation and recruitment of signaling molecules into a lipid raft. Cbp/PAG is a Csk-associated membrane adapter protein exclusively localized in a lipid raft. We identified NHERF/EBP50 as a Cbp-binding molecule, which connects the membrane raft and cytoskeleton by binding to both Cbp through its PDZ domain and ezrin-radixin-moesin through the C terminus. Overexpression of Cbp reduced the mobility of the raft on the cell surface of… CONTINUE READING

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