Cutting edge: murine dendritic cells require IL-15R alpha to prime NK cells.

@article{Koka2004CuttingEM,
  title={Cutting edge: murine dendritic cells require IL-15R alpha to prime NK cells.},
  author={Rima M Koka and Patrick R. Burkett and Marcia Chien and Sophia Chai and David L. Boone and Averil Ma},
  journal={Journal of immunology},
  year={2004},
  volume={173 6},
  pages={3594-8}
}
NK cells protect hosts against viral pathogens and transformed cells, and dendritic cells (DCs) play important roles in activating NK cells. We now find that murine IL-15Ralpha-deficient DCs fail to support NK cell cytolytic activity and elaboration of IFN-gamma, despite the fact that these DCs express normal levels of costimulatory molecules and IL-12. By contrast, IL-15Ralpha expression on NK cells is entirely dispensable for their activation by DCs. In addition, blockade with anti-IL… CONTINUE READING

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