Cutting edge: murine CD59a modulates antiviral CD4+ T cell activity in a complement-independent manner.

@article{Longhi2005CuttingEM,
  title={Cutting edge: murine CD59a modulates antiviral CD4+ T cell activity in a complement-independent manner.},
  author={Maria P Longhi and Baalasubramanian Sivasankar and Nader Omidvar and Bryan Morgan and Awen Gallimore},
  journal={Journal of immunology},
  year={2005},
  volume={175 11},
  pages={
          7098-102
        }
}
CD59 blocks formation of the membrane attack complex of complement by inhibiting binding of C9 to the C5b-8 complex. To investigate a role for CD59 in promoting T cell responses, we compared T cell activation in CD59a-deficient (Cd59a-/-) and wild-type (WT) mice after in vitro stimulation and after infection with rVV. Virus-specific CD4+ T cell responses were significantly enhanced in Cd59a-/- mice compared with WT mice. Similarly, Cd59a-/- T cells responded more vigorously to in vitro… CONTINUE READING

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