Cutting edge: mouse CD300f (CMRF-35-like molecule-1) recognizes outer membrane-exposed phosphatidylserine and can promote phagocytosis.

@article{Choi2011CuttingEM,
  title={Cutting edge: mouse CD300f (CMRF-35-like molecule-1) recognizes outer membrane-exposed phosphatidylserine and can promote phagocytosis.},
  author={Seung-Chul Choi and Venkateswara Rao Simhadri and Linjie Tian and Aleksandra Gil-Krzewska and Konrad Krzewski and Francisco Rubio Borrego and John E. Coligan},
  journal={Journal of immunology},
  year={2011},
  volume={187 7},
  pages={3483-7}
}
Reportedly, CD300f negatively regulates interactions between dendritic and T cells and acts as an anti-inflammatory molecule in a multiple sclerosis mouse model. We found that a CD300f/Fc chimeric protein specifically binds to apoptotic/dead splenocytes and to apoptotic cells from starved or irradiated lymphocytic cell lines, an observation extended to insect cells. CD300f also binds PMA/ionomycin-activated splenocytes and Ag-stimulated T cells, an interaction inhibited by Annexin V. By ELISA… CONTINUE READING
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