Cutting edge: mast cells regulate disease severity in a relapsing-remitting model of multiple sclerosis.

@article{Sayed2011CuttingEM,
  title={Cutting edge: mast cells regulate disease severity in a relapsing-remitting model of multiple sclerosis.},
  author={Blayne Amir Sayed and Margaret E. Walker and Melissa A Brown},
  journal={Journal of immunology},
  year={2011},
  volume={186 6},
  pages={3294-8}
}
Mast cells (MCs) exert a significant pathologic influence on disease severity in C57BL/6 (B6) strain-dependent experimental allergic encephalomyelitis (EAE), a model of primary progressive multiple sclerosis (MS). However, relapsing-remitting MS, which is modeled in SJL mice, is the more prevalent form. Given genetically determined heterogeneity in numbers and responsiveness of MCs from various strains of mice, we asked whether these cells also influence this more clinically relevant MS model… CONTINUE READING

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