Cutting edge: mast cells critically augment myeloid-derived suppressor cell activity.

@article{Saleem2012CuttingEM,
  title={Cutting edge: mast cells critically augment myeloid-derived suppressor cell activity.},
  author={Sheinei J. Saleem and Rebecca K. Martin and Johanna K. Morales and Jamie L Sturgill and David Gibb and L. J. Graham and Harry D Bear and Masoud H Manjili and John Jake Ryan and Daniel H Conrad},
  journal={Journal of immunology},
  year={2012},
  volume={189 2},
  pages={511-5}
}
Myeloid-derived suppressor cells (MDSCs) are primarily recognized for their immunosuppressive properties in malignant disease. However, their interaction with other innate immune cells and their regulation of immune responses, such as in parasitic infection, necessitate further characterization. We used our previously published mouse model of MDSC accumulation to examine the immunoregulatory role of MDSCs in B16 melanoma metastasis and Nippostrongylus brasiliensis infection. In this study, we… CONTINUE READING
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