Cutting edge: innate immune response triggered by influenza A virus is negatively regulated by SOCS1 and SOCS3 through a RIG-I/IFNAR1-dependent pathway.

@article{Pothlichet2008CuttingEI,
  title={Cutting edge: innate immune response triggered by influenza A virus is negatively regulated by SOCS1 and SOCS3 through a RIG-I/IFNAR1-dependent pathway.},
  author={Julien Pothlichet and Michel Chignard and Mustapha Si-Tahar},
  journal={Journal of immunology},
  year={2008},
  volume={180 4},
  pages={
          2034-8
        }
}
Influenza A virus (IAV) triggers a contagious respiratory disease that produces considerable lethality. Although this lethality is likely due to an excessive host inflammatory response, the negative feedback mechanisms aimed at regulating such a response are unknown. In this study, we investigated the role of the eight "suppressor of cytokine signaling" (SOCS) regulatory proteins in IAV-triggered cytokine expression in human respiratory epithelial cells. SOCS1 to SOCS7, but not cytokine… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 66 CITATIONS

FILTER CITATIONS BY YEAR

2008
2018

CITATION STATISTICS

  • 6 Highly Influenced Citations

  • Averaged 4 Citations per year over the last 3 years

Similar Papers

Loading similar papers…