Cutting edge: inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2.

@article{Hirschfeld1999CuttingEI,
  title={Cutting edge: inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2.},
  author={Matthew Hirschfeld and Carsten J Kirschning and Ralf Schwandner and Holger Wesche and John H. Weis and Ronald M Wooten and Janis J Weis},
  journal={Journal of immunology},
  year={1999},
  volume={163 5},
  pages={
          2382-6
        }
}
The agent of Lyme disease, Borrelia burgdorferi, produces membrane lipoproteins possessing potent inflammatory properties linked to disease pathology. The recent association of toll-like receptors (TLR) 2 and 4 with LPS responses prompted the examination of TLR involvement in lipoprotein signaling. The ability of human cell lines to respond to lipoproteins was correlated with the expression of TLR2. Transfection of TLR2 into cell lines conferred responsiveness to lipoproteins, lipopeptides, and… CONTINUE READING

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