Cutting edge: induced indoleamine 2,3 dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansion.

@article{Mellor2003CuttingEI,
  title={Cutting edge: induced indoleamine 2,3 dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansion.},
  author={Andrew L Mellor and Babak Baban and Phillip R. Chandler and Brendan Marshall and Kanchan Jhaver and Anna M Hansen and Pandelakis A Koni and Makio Iwashima and David H. Munn},
  journal={Journal of immunology},
  year={2003},
  volume={171 4},
  pages={1652-5}
}
In mice, immunoregulatory APCs express the dendritic cell (DC) marker CD11c, and one or more distinctive markers (CD8alpha, B220, DX5). In this study, we show that expression of the tryptophan-degrading enzyme indoleamine 2,3 dioxygenase (IDO) is selectively induced in specific splenic DC subsets when mice were exposed to the synthetic immunomodulatory reagent CTLA4-Ig. CTLA4-Ig did not induce IDO expression in macrophages or lymphoid cells. Induction of IDO completely blocked clonal expansion… CONTINUE READING

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