Cutting edge: impaired MHC class I expression in mice deficient for Nlrc5/class I transactivator.

@article{Biswas2012CuttingEI,
  title={Cutting edge: impaired MHC class I expression in mice deficient for Nlrc5/class I transactivator.},
  author={Amlan Biswas and Torsten B. Meissner and Taro Kawai and Koichi Kobayashi},
  journal={Journal of immunology},
  year={2012},
  volume={189 2},
  pages={516-20}
}
MHC class I and class II are crucial for the adaptive immune system. Although regulation of MHC class II expression by CIITA has long been recognized, the mechanism of MHC class I transactivation has been largely unknown until the recent discovery of NLRC5/class I transactivator. In this study, we show using Nlrc5-deficient mice that NLRC5 is required for both constitutive and inducible MHC class I expression. Loss of Nlrc5 resulted in severe reduction in the expression of MHC class I and… CONTINUE READING

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