Cutting edge: human latency-associated peptide+ T cells: a novel regulatory T cell subset.

@article{Gandhi2010CuttingEH,
  title={Cutting edge: human latency-associated peptide+ T cells: a novel regulatory T cell subset.},
  author={Roopali Gandhi and Mauricio Franco Farez and Yue Huan Wang and Deneen Kozoriz and Francisco Jos{\'e} L{\'o}pez Quintana and Howard L. Weiner},
  journal={Journal of immunology},
  year={2010},
  volume={184 9},
  pages={
          4620-4
        }
}
Regulatory T cells (Tregs) play an important role in the maintenance of peripheral tolerance. Several molecules including TGF-beta have been linked to the function and differentiation of Tregs. In this study, we describe a unique population of T cells expressing a membrane bound form of TGF-beta, the latency-associated peptide (LAP), and having regulatory properties in human peripheral blood. These CD4(+)LAP(+) T cells lack Foxp3 but express TGF-betaR type II and the activation marker CD69. CD4… CONTINUE READING
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