Cutting edge: genetic variation influences Fc epsilonRI-induced mast cell activation and allergic responses.

@article{Yamashita2007CuttingEG,
  title={Cutting edge: genetic variation influences Fc epsilonRI-induced mast cell activation and allergic responses.},
  author={Yumi Yamashita and Nicolas Charles and Yasuko Furumoto and Sandra Odom and Toshiyuki Yamashita and Alasdair M. Gilfillan and St{\'e}phanie Constant and Molly A. Bower and John Jake Ryan and Juan Francisco Rivera},
  journal={Journal of immunology},
  year={2007},
  volume={179 2},
  pages={740-3}
}
Mast cell responses are influenced by a diverse array of environmental factors, but little is known about the effect of genetic background. In this study, we report that 129/Sv mice had high levels of circulating IgE, increased expression of the high-affinity receptor for IgE (Fc epsilonRI), and greater sensitivity to anaphylaxis when compared with C57BL/6 mice. Bone marrow-derived mast cells (BMMCs) from 129/Sv mice showed more robust degranulation upon the engagement of Fc epsilonRI… CONTINUE READING